In a branch of the PI3K protein family — with members named PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ — PI3Kβ was long treated as the proverbial middle child: neglected by cancer scientists in favor of its more prominent siblings. In a new study, Dana-Farber researchers demonstrate that it doesn’t deserve its obscurity — that in fact … Read more
In general, standard of care is treatment accepted by medical experts for a certain type of disease and that is widely used by healthcare professionals. It is also called best practice, standard medical care, and standard therapy. The National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology lay out the recognized standards for cancer … Read more
By Valerie Frank Ever since I can remember, I’ve made people laugh. I was always the funny friend, and when I was in my mid-20s I made it official by becoming a Main Stage cast member of ImprovBoston — an improvisational comedy theater in Cambridge, MA. Once I retired from improv to become a suburban … Read more
More than seven percent of adults in the US identify as LGBTQ+, according to a 2022 Gallup poll. That’s a record high and a doubling of the percentage measured a decade earlier. People in the LGBTQ+ community can face many societal barriers, including to healthcare. According to multiple surveys, about one in three LGBTQ+ people … Read more
Although hemorrhoids and colon cancer share certain symptoms, such as rectal bleeding, they are very different conditions. People who experience symptoms of either should get evaluated by a physician: while hemorrhoids are far more common than colon cancer, an exam is necessary to determine which one, if either, a patient has and how it should … Read more
One of the ways of classifying breast cancers is by the level of a protein called HER2 on the surface of tumor cells. HER2, which stands for human epidermal growth factor receptor 2, helps control how breast cells grow, divide, and repair damage. Breast cancers marked by high levels of HER2 are known as HER2-positive … Read more
Just over a year after giving birth to her son, Emmett, Abigail Myers faced a devastating diagnosis of breast cancer in March 2014. It started when Myers woke up one morning feeling sore. When she found a lump, she rushed to her doctor, all the while in disbelief that she might have cancer. A resident … Read more
When the time came for Jeffrey Ferreira to undergo a stem cell transplant for acute myeloid leukemia (AML), his Dana-Farber hematologist, Corey Cutler, MD, MPH, had some intriguing news: he was eligible for a clinical trial of a new approach to lowering the risk of chronic graft-versus-host disease (GVHD), a common and sometimes severe aftereffect … Read more
Bone marrow is the soft, spongy material inside our bones. Occupying one of the most protected places in the body, it produces nearly all the components of blood. These include red blood cells, which deliver oxygen throughout the body, white blood cells, which help fight disease, and platelets needed for clotting. The marrow generates approximately … Read more
A stem cell transplant is one of the most powerful tools doctors have for treating certain kinds of cancers and blood-related diseases. The “grafted” cells involved in a transplant are known as hematopoietic stem cells, meaning they’re able to develop into all types of blood cells — red blood cells, which deliver oxygen throughout the … Read more
For close to a year, Melanie Spears had been experiencing abdominal pain and constipation. As an Army veteran who had served in Afghanistan, she was used to pushing through adversity — so she tweaked her diet and dealt with what doctors diagnosed as irritable bowel syndrome. Only after microscopic blood samples in her stool led … Read more
Over the past three decades, the number of cancer survivors has increased. That trend is expected to continue. The numbers indicate progress in the treatment of cancer, but they also underscore the importance of quality of life after cancer. “We want people to lead healthy, productive, enjoyable lives, and mobility is such an important piece … Read more
Words like “chemobrain” and “chemofog” — terms now used by patients, doctors, and scientists to describe cognitive decline that some patients experience in response to cancer therapy — didn’t exist a few decades ago. Today, however, there’s a general awareness that cancer treatments can take a toll on the brain. Oncologists don’t yet have a … Read more
Stem cell transplantation refers to transplants of blood-forming stem cells taken from the bone marrow or collected from the bloodstream. Autologous transplants use the patient’s own stem cells, while allogeneic transplants use stem cells provided by a donor. Stem cell transplants offer some patients with blood-related cancers such as leukemia, lymphoma, and multiple myeloma the … Read more
When scientists named microglial cells after the Greek word for “glue,” they thought it conveyed all one needed to know about the cells. The cells’ role, it was believed, began and ended with providing connective tissue for neurons, the information carriers of the nervous system. Research over many years has shown that moniker to … Read more
A gene mutation is a change in the genetic instructions in a cell. Genes are the DNA-encoded instructions for building proteins, which are the machinery that does the work inside our cells and our bodies. Some mutations change the function of proteins in ways that increase the risk of cancer or drive its growth. Gene … Read more
When Chuck Stravin was diagnosed with renal cell carcinoma in 2015, one of his biggest fears was not living long enough to see his four young daughters get married. The disease later metastasized to his lungs as stage IV cancer, but thanks to groundbreaking clinical trials and a care team he considers family, Stravin is … Read more
Hodgkin lymphoma (sometimes called Hodgkin’s lymphoma) is a form of cancer that affects the immune system. It starts in the white blood cells, but what patients and doctors will most likely notice first is a lump in the neck, under the arm, or in the groin. How is Hodgkin lymphoma staged? Hodgkin lymphoma is staged … Read more
Ovarian cancer almost always starts in the fallopian tubes. It’s counterintuitive. Why is it called ovarian cancer if it doesn’t start there? For a long time, the ovaries were assumed to be the source because that is where the cancer is concentrated at the time of diagnosis. But about 20 years ago, researchers took a … Read more
Set to begin radiation therapy the next day, the patient was anxious. Not just about her thoracic cancer treatment, but also about the oral chemotherapy she took at home. It came with high insurance copays. Then came a phone call that eased her concerns. As they had earlier in her treatment, members of Dana-Farber’s Specialty … Read more