It was a celebratory moment, in more ways than one. Kalina Martel and her teammates on the EVO travel softball team had just won their final summer tournament, and as the middle schoolers hugged and high-fived on the diamond, a steady stream of bubbles rose above them — courtesy of Kalina’s then-two-year-old brother Kole. Kole … Read more
The differences between cancers in adults and children go well beyond age. In many respects, they are markedly different diseases.
In February 2024, while being treated for pneumonia, doctors noticed that Rebecca Santorelli’s spleen was enlarged. “No one was concerned at first,” recalls Santorelli, 61, who lives outside of Albany, New York. Doctors estimate spleen size with fingerbreadths — or approximate widths of a finger — below the rib cage, with normal being about zero. … Read more
What makes us humans lies in our genes. But even with all their power, they are remarkably vulnerable to errors. But these potentially harmful errors are an opportunity for humankind to study and treat, as it has been for Dana-Farber’s physician-scientist Srinivas Viswanathan, MD, PhD. “We have the ability to make an impact,” Viswanathan said. “There are so many unanswered questions in cancer biology still, especially in our understanding of rarer subtypes of kidney cancer.” One of these subtypes — called translocation renal cell carcinoma (tRCC) — occurs when a gene quietly moves, fuses with another gene, and … Read more
When Pedro Vianna, MD, was 5 years old, his mother took him to the pediatrician in their home country of Brazil. A lymph node on the left side of his neck had been swollen for weeks. While the pediatrician reassured his family that it was likely a reactive viral infection, Vianna’s mother, a hematologist, had … Read more
Dana-Farber physician-scientists presented results of more than 100 research studies at the 66th American Society of Hematology (ASH) annual meeting. Scientists shared findings across a range of hematologic disorders, underscoring the Institute’s dedication to innovation in hematologic oncology research, advances in early disease detection and intervention, and improving patient outcomes. ASH is the world’s most comprehensive hematology … Read more
Dana-Farber strongly encourages patients to get vaccinated for COVID-19 to protect themselves from serious infection of the virus. Family members, caregivers, and frequent household contacts also should also stay up to date with vaccinations to protect those around them. COVID-19 vaccines have been given to millions of people and have proven safe and effective at … Read more
The Dana-Farber lab of Kira Bona, MD, MPH, has uncovered an alarming reality: children from low-income households are more likely to experience cancer relapse and face lower survival rates compared to their more privileged peers, despite receiving treatment on highly standardized clinical trials at top academic centers. The number of children for whom these data … Read more
Ruth Nelson struggled with her new breast cancer diagnosis mentally and physically. On treatment, her cardiac health faltered, her blood pressure spiked, and she experienced an unexplained episode in which she briefly lost her speech. And on top of that, she felt as if she were “a problem to be managed” by her friends and … Read more
As a pediatric pharmacist located in Dana-Farber’s Jimmy Fund Clinic, Patrick never tires of seeing smiling, young cancer patients enjoying the clinic’s playroom. The resilience they display throughout infusions, blood draws, and other procedures not only inspires him, but it also serves as a source of resolve he carries into his ongoing cancer care. Patrick, … Read more
What does “refractory” mean medically? The word “refractory” in general use means stubborn or intractable, and in medicine it is specifically applied to disease that does not respond to treatment. Refractory cancer refers to cancer that may be resistant to initial therapy or becomes resistant during treatment. “We would consider disease refractory if doesn’t respond … Read more
The views discussed in this piece do not represent the U.S. Government. Sara Minkara lost her sight at the age of seven due to juvenile macular degeneration — a rare genetic condition — but she has never allowed that to slow her down. Once she grew up, she made her life’s goal helping the world … Read more
Results of several phase 3 trials and dozens of other studies led by Dana-Farber researchers were presented online and in person June 3-7 at the 2022 Annual Meeting of the American Society of Clinical Oncology (ASCO), the world’s largest clinical cancer research meeting. Some of the research reports presented by Dana-Farber investigators include: Improved progression-free … Read more
Hemoglobin is an essential protein in your red blood cells that carries oxygen to your body’s organs and tissues and transports carbon dioxide from your organs and tissues back to your lungs. What type of cancer causes low hemoglobin? Anemia is essentially a blood condition marked by a low level of hemoglobin and red blood cells, and in some cases … Read more
This post was adapted from a Broad Institute post by Allessandra DiCorato. Over the last two decades, researchers have discovered thousands of genetic mutations in cancer. But understanding how they affect the growth and spread of tumors in the body remains challenging because each patient’s tumor can have many different mutations. Now, scientists have used … Read more
Dana-Farber scientists have found that a generic anti-microbial drug can block a key molecular driver of chronic lymphocytic leukemia (CLL) cells, and when tested in a small clinical trial of advanced CLL patients who had relapsed, the drug slowed disease progression in half of them. The drug, pyrimethamine, achieved stable disease in eight of the … Read more
The last two school years will be remembered for the tremendous challenges they presented students due to COVID-19, but rising second-grader Caroline McMahan and her family were ready for the pandemic’s limitations after what they had already endured. By the time the pandemic began, Caroline, 7, was already adept at washing up, masking up, and … Read more
Anna Nazarenko doesn’t see herself as sick. The strong-willed, spunky 6-year-old loves to dance and ski, and spent much of April Fool’s day pranking her parents. Aside from the enzymes she takes to help digest her food, you wouldn’t know that she has Shwachman-Diamond syndrome (SDS). The rare, inherited type of bone marrow failure has also … Read more
Treatment advances for multiple myeloma continue to bring improved outcomes for patients in different stages of their disease. Recent clinical trial reports show progress in treating two myeloma populations — newly diagnosed, transplant eligible patients, and individuals whose disease has progressed following several lines of therapy. In one trial, the phase 2 GRIFFIN study showed … Read more
This post originally appeared on Discoveries, the blog of Boston Children’s Hospital. A drug used for rheumatoid arthritis has moved a step closer to U.S. Food and Drug Administration (FDA) approval for a desperately needed new use. The drug, abatacept, has gained FDA breakthrough therapy designation for preventing acute, severe graft-versus-host disease (GVHD) in patients receiving bone … Read more