Protein degradation is a natural process by which cells break down proteins that are damaged or no longer needed so they can be recycled or disposed of. Scientists at Dana-Farber and elsewhere are harnessing this process to destroy specific proteins involved in cancer, an approach known as targeted protein degradation. In contrast to traditional targeted … Read more
Arliene T. Penn entered the Mrs. Globe pageant in 2023 not to win a title, but rather to spread a very important message on a very large stage. In the end, she did both. Competing as Mrs. British Virgin Islands, Penn reached the semifinals of the international event. Far more important to her, however, was … Read more
Clinical trials are scientific studies in which new treatments — drugs, diagnostic procedures, and other therapies — are tested in people to find out if they are safe and effective. Nearly all cancer drugs in use today were tested in clinical trials. If you have been diagnosed with cancer, the benefits of participating in a clinical … Read more
An ovarian cyst is not the same as ovarian cancer. Benign ovarian cysts are extremely common, while ovarian cancer is rare. They do share symptoms, such as abdominal bloating, pressure, pain, or swelling. A gynecologist can help you determine if you have a benign ovarian cyst and if you need treatment. Many cysts go away … Read more
Inflammation is normal. It’s an essential process our bodies use to fight infections and heal wounds. But inflammation that persists can be harmful, and in some cases can increase the risk of cancer.
A recent phase 1 trial of a form of cellular gene therapy for sickle cell disease (SCD) conducted at Dana-Farber/Boston Children’s Hospital showed promise that led to an ongoing nationwide phase 2 initiative. Among the authors of the paper describing the results were six unsung heroes whose behind-the-scenes efforts made such a trial possible. Those unsung heroes … Read more
With the season of sniffles and sneezes upon us, it’s integral to ensure your immune system is shored up. The immune system is a complicated mechanism that defends you from bacteria and viruses, and it’s especially important for many people undergoing treatment for cancer. Many chemotherapies damage the immune system as they attack all fast-growing … Read more
Waldenström macroglobulinemia, a rare form of non-Hodgkin lymphoma, has its share of eccentricities. One of the hallmarks of the disease, for example, is an overabundance of a particular protein, yet other conditions may also have that feature. It’s also not unusual for patients to have very high protein levels but have no symptoms or mild … Read more
Alanna Devlin Ball, LCDR, USN (Ret), and Alexandra Takacs, MSN, RN, both knew from an early age that they wanted to join the military. And while neither of these veterans envisioned cancer as part of their future, they agree that their service experiences helped shape their time at Dana-Farber. Ball, a medically retired Navy lieutenant … Read more
The same way you can predict whether a family is away, getting ready for work, or cooking dinner by observing which lights are on in the house, scientists can gaze into a cell and predict its state based on which genes are on or off. Normal liver cells, for instance, have a predictable and recognizable … Read more
Prostate cancer is the second most common cause of cancer in men worldwide as of 2020, and cases of advanced prostate cancer continue to rise. Early detection of prostate cancer is essential for effective treatment. Dana-Farber physicians recommend having a conversation with a medical professional about screening around the age of 40, or perhaps even … Read more
Investigators who run investigator-initiated trials (IITs) have two essential qualities. One is curiosity, which keeps them alert, aware of discoveries, and able to make connections that lead to new treatment ideas. The second is determination. “The burden of responsibility for what is typically a many-year-long study falls on that one investigator,” says Ursula Matulonis, MD, … Read more
A frequent component of treatment for breast cancer is surgery to remove the cancer. While mastectomy was more common in decades past, experts at Dana-Farber want you to know that science and treatment have advanced. Improved screening, early diagnosis, and advances in medicine are enabling many more patients to have the option of breast-conserving surgery, … Read more
What is NUT carcinoma? NUT carcinoma, formerly known as NUT-midline carcinoma, is a rare but very aggressive cancer that can develop anywhere in the body but usually starts in the head, neck, and lungs. It’s a squamous cell cancer — meaning it begins in squamous cells, which line hollow organs such as the windpipe and … Read more
Laura Orfanedes was worried that she was going to end up with breast cancer. No one in her family had it, and yet she could not shake the feeling. So she took action. She went in for her first mammogram at age 40. In December 2009, at age 43, her annual scan showed an area … Read more
Patti Keenan was a senior in high school before learning that the mysterious disease she was treated for twice as a young girl in the 60s was, in fact, a rare form of cancer. Her parents, not wanting to frighten Patti at a time when pediatric cancer survival rates were much lower, kept their daughter’s … Read more
In the fall of 2019, John Brazeau’s back pain got so bad that it interfered with his ability to engage in the two hobbies he loved most in his retirement on Cape Cod: golfing and clamming. Despite keeping up with physical therapy exercises meant to relieve the pain, it wasn’t diminishing. Then in 2020, Brazeau … Read more
David Trueblood’s long career in journalism was shaped by new technology, including the rise of digital photography and the impact of online media. So, upon learning in early 2023 that he would need a stem cell transplant due to myelodysplastic syndrome (MDS), a rare blood disorder impacting his bone marrow, Trueblood appreciated the role innovation … Read more
Jake Maguire was just three days away from his sixth birthday when he was diagnosed with acute lymphoblastic leukemia (ALL). Encouraged by his father, a gym teacher, the young Maguire was already in love with sports, especially baseball. Now 23 and over a decade out of treatment, that love is still strong, and Maguire is … Read more
There are several types of lung cancer. On a basic level, lung cancers fall into two main subtypes: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). Just as each person is unique, every lung cancer is unique. At Dana-Farber’s Lowe Center for Thoracic (Lung) Cancer Treatment Center, oncologists work with a team … Read more