How is DNA Sequencing Used in Cancer Therapy?

Cancer therapy is increasingly aimed at the fundamental abnormalities within cancer cells – the genes and proteins that normally keep cell division under control, but are damaged or faulty in tumor cells. To understand which genes are abnormal, where they’re located within the genome, and how they affect cell growth, doctors and scientists use a … Read more

Stomach Cancer: How Immunotherapy and Targeted Therapy are Changing Treatment

The approval of a targeted therapy and an immunotherapy drug for some patients with advanced stomach cancer reflects recent new approaches to this difficult-to-treat cancer that hasn’t had many therapeutic advances in recent years. Stomach cancer, uncommon in the United States but a leading cause of cancer death globally, causes few definitive symptoms in early … Read more

Inoperable Cancer: What Does it Mean?

A cancer can be inoperable for a variety of reasons. “Liquid cancers,” such as leukemia, lymphoma, and multiple myeloma, are considered inoperable by nature, because they involve cells or tissues that are dispersed throughout the body. Leukemia and multiple myeloma, for example, originate in abnormal cells of the bone marrow, the spongy material within the … Read more

CRISPR Enables Cancer Immunotherapy Drug Discovery

This originally appeared on Vector, Boston Children’s Hospital’s blog. A novel screening method using CRISPR-Cas9 genome editing technology has revealed new drug targets that could potentially enhance the effectiveness of PD-1 checkpoint inhibitors, a promising new class of cancer immunotherapy. The method, developed by a team at Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, uses … Read more

Apricot Seeds: Do They Fight Cancer?

Although they were thoroughly debunked in the 1970s as anti-cancer agents, products made from apricot pits continue to be aggressively marketed to unsuspecting patients, according to a recent report in BuzzFeed. Do apricot seeds fight cancer? What is vitamin B17? The idea that such products could fight cancer arose because apricot pits contain a substance … Read more

What is CRISPR and How Can It Help Cancer Research?

CRISPR, a powerful new tool for editing the DNA instruction manual in animals and humans, is proving a boon to cancer research. Scientists say CRISPR has dramatically accelerated the process of making animal models of cancer and is speeding the search for new molecular targets for cancer drugs. The technique is also being used in … Read more

Treating Cancer by Location or Genetic Markers: Which is Better?

In the past, treating cancers involved classifying them primarily by the organ or tissue where they arose – like the skin, the lungs, the breast, or the colon. Today, it’s often possible to identify the genes and proteins responsible for a tumor’s growth, and, in some cases, to offer a drug treatment that specifically targets … Read more

Cancer Treatment: A Look at How It Has Evolved in 70 Years

In 1947, when Dana-Farber Cancer Institute founder Sidney Farber, MD, set out to find a drug treatment for childhood leukemia, cancer treatment took two forms – surgery to cut out cancerous masses, and radiation therapy to burn them out. Cancers that couldn’t be removed or irradiated – either because of their position in the body, because … Read more

Diabetes and Cancer: What’s the Link?

People with diabetes are at higher risk for some, but not all, forms of cancer. The relationship between the two diseases is complex and surrounded with unanswered questions. The strongest links are for cancers of the liver, pancreas, and endometrium, which are twice as likely to occur in people with Type 2 diabetes, according to … Read more