Cancer research
What’s New in Immunotherapy for Kidney Cancer?

Kidney cancer is one of several cancers that has responded well to immunotherapy drugs, which can free the immune system from restraints that cancer cells can impose on it. The drug nivolumab (Opdivo), for example, which was recently approved, can extend survival in patients with metastatic kidney cancer after other […]

March 23, 2017
0
Cancer research
What’s New in Immunotherapy and Melanoma? [Webchat]

Cancer immunotherapy is a kind of cancer treatment that mobilizes the patient’s immune defenses to recognize and attack tumor cells. It is now the treatment of choice for many patients with advanced melanoma, according to Elizabeth I. Buchbinder, MD, a melanoma specialist at Dana-Farber. “Immunotherapy has taken off,” Buchbinder says, “There […]

March 14, 2017
0
Cancer research
Firefighters and Cancer: Dana-Farber Scientists Investigate

A fire truck pulls into the truck bay and idles for a minute or two as a firefighter attaches tubing to filter the exhaust out of the station. The firefighter’s face may be close to the exhaust for 30 seconds while the tubing is attached. It’s a routine task, one […]

February 27, 2017
3
Cancer research , Care for children
Do Childhood Leukemia Patients with Down Syndrome Need Modified Therapy?

Because of their increased susceptibility to the toxicities of chemotherapy, should ALL patients with Down syndrome receive modified treatment to minimize this risk? Or should they be given the same treatment as other children with ALL, to minimize the chance for relapse?

February 17, 2017
0
Cancer research , General interest
Which Countries Have the Highest Rates of the World’s Most Common Cancers? [INFOGRAPHIC]

Cancer occurs worldwide, and commonly – in 2012, there were an estimated 14.1 million new cancer cases globally, according to the World Cancer Research Fund. But not all cancers are created equally. Certain countries have higher rates of some cancers and lower of others, depending on a number of factors, […]

February 3, 2017
0
Cancer research , Care for adults
Who Needs Chemotherapy after Treatment for Early Breast Cancer?

Following surgery and/or radiation for early stage breast cancer, chemotherapy is sometimes given to eliminate remaining cancer cells that could cause trouble later. Traditionally, women have been more likely to undergo follow-up chemotherapy if clinical and pathological factors suggested a significant risk of recurrence, such as a larger tumor, higher […]

February 2, 2017
1
Cancer research
Can a Serum Biomarker Predict Response to Immunotherapy?

This post originally appeared on Cancer Research Catalyst, a blog from the American Association of Cancer Research (AACR). By Srivani Ravoori, PhD Immunotherapy, particularly a class of immunotherapeutics called immune checkpoint inhibitors, has transformed the treatment of several types of cancer in recent years. So far, the U.S. Food and […]

January 26, 2017
1
Cancer research
Why Is It Difficult to Pinpoint the Exact Cause of a Person’s Cancer?

A diagnosis of cancer always comes as a shock, and the patient naturally asks the physician, why did this happen? Is it something I did or didn’t do, or did I inherit it, or were chemicals in the environment to blame? “Why patients develop cancers is not well known,” explains […]

January 23, 2017
0
Cancer research
How Do I Find The Right Clinical Trial For Me?

Clinical trials are research studies that explore whether new treatments, diagnostic techniques, or disease-prevention strategies are safe and effective in patients. They may be an option when patients no longer benefit from standard therapies. They may also offer an alternative to standard therapies, particularly if the agent being tested is […]

January 17, 2017
0
Cancer research
Experts Forecast Cancer Research and Treatment Advances in 2017

This post originally appeared on Cancer Research Catalyst, the official blog of the American Association for Cancer Research. By Srivani Ravoori, PhD As we step into 2017, a big question looming in the minds of all stakeholders in the cancer research arena is: What is the future of cancer research […]

January 10, 2017
0
Cancer research
Study Shows New Drugs Expose Vulnerability of Breast Tumors

“If it’s not broke, don’t fix it” may be a valid philosophy in general, but not in dealing with the molecular machinery of cancer cells. There, the applicable motto might be might be, “If it’s broke, keep it that way.” That’s the approach taken by a class of targeted drugs […]

December 20, 2016
0
Cancer research , General interest
Is Marijuana Use Connected to Cancer?

In November, four states – California, Massachusetts, Nevada, and Maine – passed measures legalizing marijuana for recreational use, bringing the total number of states with legal cannabis to eight, plus the District of Columbia. The vote in Maine was quite close and is expected to be challenged by opponents, but […]

December 15, 2016
4
Cancer research , General interest
21st Century Cures Act Will Support ‘Revolutionary’ Cancer Research

On Dec. 13, President Barack Obama signed into law the 21st Century Cures Act, legislation that includes significant funding to the National Institutes of Health (NIH) to further the Beau Biden Cancer Moonshot, and to the Food and Drug Administration (FDA) to speed the drug approval process. Laurie Glimcher, MD, […]

December 14, 2016
0
Cancer research , Care for adults
A New Approach to Understanding Breast Cancer Treatment Resistance

By Srivani Ravoori, PhD, American Association for Cancer Research This post first appeared on the Cancer Today website. In a study presented Dec. 7 at the San Antonio Breast Cancer Symposium, researchers conducted genomic analysis of estrogen receptor (ER)-positive metastatic breast cancer samples that had become resistant to therapies. They found […]

December 9, 2016
1
Cancer research , General interest
What Is Adjuvant Therapy?

Adjuvant therapies are drug treatments that breast cancer patients receive after surgery to prevent cancer from returning. These treatments may include chemotherapy, anti-estrogen therapy, or anti-HER2 therapy. Watch More: Young and Strong Program Helps Young Women With Breast Cancer Life After Inflammatory Breast Cancer “This is now a widely established […]

December 2, 2016
0
Cancer research
Can Immunotherapy Help Patients with Pancreatic Cancer?

Patients with pancreatic cancer often ask Dana-Farber’s Brian Wolpin, MD, MPH, about immunotherapy, the rising star of cancer treatment that’s making impressive gains against many types of malignancies. Immunotherapy drugs, which mobilize the patient’s immune defenses to recognize and attack tumor cells, have worked against lethal cancers such as melanoma […]

November 30, 2016
0
Cancer research , General interest
What Are Carcinoid Tumors?

Carcinoid tumors are rare, often slow-growing tumors that form from neuroendocrine cells found throughout the body. Carcinoid tumors most commonly arise in the gastrointestinal system, including the appendix, small intestine, or rectum, but may occur in other sites, including the lungs. In most cases, there is no clear cause of […]

November 25, 2016
1
Cancer research , Health and wellness
How to Quit Smoking: What We Know

Smoking cigarettes contributes to 80 percent of lung cancer deaths in women and 90 percent of lung cancer deaths in men, and it is estimated to have caused more than 130,000 deaths from the disease between 2005 and 2010. But smoking damage does not stop with lung cancer: the habit […]

November 17, 2016
0
Cancer research
Use of Immunotherapeutic Expanded to Fifth Type of Cancer

This post originally appeared on Cancer Research Catalyst, the official blog of the American Association of Cancer Research. By Karen Honey, PhD On Thursday, the U.S. Food and Drug Administration (FDA) announced that it had approved expanding the use of the immunotherapeutic nivolumab (Opdivo) to include the treatment of certain […]

November 15, 2016
4
Cancer research
What Are Tumor Markers?

Blood tests for the presence of substances called tumor markers can be helpful in diagnosing cancer and assessing how well treatment is working. But such tests alone generally can’t tell for certain whether someone has cancer or not. That’s why they are used in conjunction with other methods, such as […]

October 27, 2016
0
Cancer research
Immunotherapy Beats Chemotherapy for Advanced Bladder Cancer Patients

The immunotherapy drug pembrolizumab (Keytruda) is the first therapy of any kind to improve survival in patients whose metastatic bladder cancer worsened after treatment with platinum-based chemotherapy. Keytruda proved so much better than chemotherapy in this “second-line” use that an international clinical trial was halted when the advantage became apparent. […]

October 21, 2016
0
Cancer research
Drug Prolongs Remissions in Some Relapsed Ovarian Cancers

For women with relapsed ovarian cancer that responds to platinum-based chemotherapy, a drug that hampers cancer cells from repairing damaged DNA can significantly lengthen the period in which the disease is held in remission, according to a new study by Dana-Farber researchers and international collaborators. In a phase three clinical […]

0
Cancer research , General interest
What Can Be Learned from Clinical Trials that Fail?

When a clinical trial shows that a new treatment is no better than the standard, it can be disappointing. But such outcomes yield valuable, potentially lifesaving information. Trials can “fail” if the experimental therapy doesn’t work better than current treatments. These “negative” outcomes are important for several reasons. They can […]

October 14, 2016
0
Cancer research , Care for adults
What Are Aromatase Inhibitors?

Aromatase inhibitors are drugs given to patients with hormone-receptor-positive breast cancer (HR+). They target the aromatase enzyme, which helps produce female hormones such as estrogen. Estrogen drives the growth of many HR+ tumors, and these drugs help control estrogen production, says Harold Burstein, MD, PhD, a breast cancer specialist in […]

October 6, 2016
0
Cancer research
Genetics vs. Genomics: What’s the Difference?

Gene, genetics, genome, and genomics all are derived from a Greek word – gen – meaning birth or origin. Almost every aspect of health and disease is influenced in some way by the inherited information in cells, written in the chemical code of DNA and packaged in distinct units known […]

October 4, 2016
0
Cancer research
Ovarian Cancer: State of the Science

By Ursula Matulonis, MD This is an exciting time for those of us engaged in research and patient care for ovarian cancer. As we’ve learned more about this cancer – its early formation, molecular machinery, and the body’s defenses against it – we’ve also come to understand its weaknesses. An […]

September 29, 2016
0
Cancer research
What’s New in Cancer Immunotherapy?

Keeping up with progress in the field of cancer immunotherapy requires paying close attention. The number of approved drugs that help the body’s immune system fight cancer continues to grow, as does the list of different cancers in which immunotherapy is proving effective – in some cases yielding dramatically longer-lasting […]

September 27, 2016
0
Cancer research
Taking Action: Why One Cancer Patient Walks

by John O’Hara One day, I was sitting in a Dana-Farber waiting room, and I looked around at all of the people waiting with me. They were someone’s mother, father, sister, brother, child, neighbor, or friend — people just like me. And they were all facing what I was facing, […]

September 23, 2016
0
Cancer research
The Genomics Behind Blood Cancers and Other Blood Disorders

Many of the secrets of why precancerous conditions sometimes become cancerous are hidden in cells’ genes. At Dana-Farber, researchers are collecting tissue samples to see if they can pry open those secrets and unlock new treatment options for certain types of blood cancers and other blood disorders. They’re also exploring […]

September 13, 2016
0
Cancer research
Do Hot Drinks Increase the Risk of Esophageal Cancer?

Based on a review of numerous scientific studies, the International Agency for Research in Cancer (IARC) recently concluded that routine consumption of “very hot” drinks probably raises the risk of esophageal cancer. The review, by a panel of 23 experts around the world, found that drinking beverages such as coffee […]

September 6, 2016
0
Cancer research , Care for adults
Precursor Blood Condition Patient Pays it Forward

When Lori Kauzlarich discovered that she had a precursor blood condition in August 2013, she sprang into action. “I was stunned,” she says. “But I decided to advocate for myself.” Precursor conditions are blood disorders that may evolve into cancers such as leukemia, Waldenström’s macroglobulinemia, and multiple myeloma. They are […]

September 2, 2016
0
Cancer research
What is the Latest Research in Endometrial Cancer?

For endometrial cancer, as for virtually every form of cancer, advances in genomics are transforming the understanding and treatment of this disease, which arises in the lining of the uterus or womb. As part of the Profile research project at Dana-Farber, Brigham and Women’s Hospital, and Boston Children’s Hospital, investigators […]

August 30, 2016
0
Cancer research , Care for adults
Can Pancreatic Cancer Be Inherited?

Most cases of pancreatic cancer develop for unknown reasons, but about 10 percent occur in families that have a strong history of the disease. That doesn’t mean that if you are a member of such a family you will develop pancreatic cancer, but rather that you are at a higher […]

August 17, 2016
1
Cancer research
How Does Cancer Spread?

Cancer is most dangerous when it has spread, or metastasized, from its original site in the body. A tumor that began as an isolated mass – often treatable by surgery and/or radiation therapy – can become a dispersed, much more difficult to treat, malignancy. For cancer to spread, several steps […]

August 10, 2016
0
Cancer research
How Do PARP Inhibitors Work In Cancer?

PARPs (or Poly (ADP-ribose) polymerases)  are proteins that play an important role in the life of a cell. When a strand of the DNA double helix is broken or damaged, PARPs  act as a repair crew to help fix the damaged site, allowing the cell to live. For healthy cells […]

July 21, 2016
0
Cancer research
What Are Precursor Blood Conditions and How Are They Treated?

Precursor conditions are early phases of blood diseases that may develop into cancers such as lymphoma, leukemia, Waldenström’s macroglobulinemia, and multiple myeloma. Most people do not experience symptoms, and since doctors rarely screen for precursor conditions, they are often diagnosed after routine blood tests. “Many diagnoses are purely incidental,” says […]

July 15, 2016
0
Cancer research
Fighting Women’s Cancers from Within

Traditionally, the war on cancer has been waged from the outside in, with therapies such as surgery, radiation, and drugs entering the body from external sources. For more than 100 years, however, a notion has persisted that the most formidable tool against cancer may come from within: the immune system. […]

June 27, 2016
0
Cancer research , Care for adults
Individualized Clinical Trial Gives Patient with Rare Cancer Time to Celebrate

Kerri Antonuccio marked her 40th birthday this spring with a fresh lease on life. For the first time since 2012, she didn’t feel too sick from cancer treatment to enjoy her big day. She was also able to travel to Mexico and serve as matron of honor at her sister’s […]

June 20, 2016
2
Cancer research
Can Vitamin D Reduce Cancer Risk?

Scientific evidence that vitamin D can help lower the risk of cancer development, as well as the risk of metastasis or recurrence, has been mixed. But several new studies point toward such a connection for certain cancers. Numerous population-tracking studies over the years have shown that higher intake or blood […]

June 17, 2016
2
Cancer research
ASCO 2016 Update: Immunotherapy and Melanoma

As one of the hottest topics in cancer research today, immunotherapy took center stage at the 2016 American Society of Clinical Oncology meeting in Chicago. Harold J. Burstein, MD, PhD, a breast oncologist in the Susan F. Smith Center for Women’s Cancers at Dana-Farber Cancer Institute, recently sat down with […]

June 15, 2016
1
Cancer research
How Can Bioinformatics Help Advance Precision Cancer Care?

Scattered amongst the letters of genetic code in a tumor cell are telltale mutations and DNA alterations that spur its malignant activity. But there are billions of letters of code and each patient’s cancer is different, with its own particular genetic changes. These changes may dictate how it behaves, how […]

May 27, 2016
0
Cancer research , Care for adults
From Cancer Researcher to Patient and Back

By Katherine Walsh When faced with something as scary and life-changing as a cancer diagnosis, the way we see the world drastically changes. My story is a literal shift – from cancer researcher to leukemia patient, and a very sick one at that. My world came to a screeching halt […]

May 23, 2016
0
Cancer research
Can Stress Affect Cancer?

Stress is generally defined as a condition in which the body or mind is placed under strain or tension. Stress is a normal part of life. In fact, studies show it to be a necessary part of life, prompting us to adapt and become more resilient. But if it becomes […]

May 19, 2016
2
Cancer research , Care for adults
A Behind the Scenes Look at the People Helping to Usher in New Cancer Therapies: A Nurse’s Story

This post originally appeared on HuffPost Impact. By Joan Lucca, RN, MSN Nearly four decades ago, I became a nurse and dedicated my life’s work to the care and comfort of patients. The ‘70s was a decade of change and opportunity as doors began to open for women in emerging […]

May 17, 2016
0
Cancer research
Team Care and Positive Attitude Help Rectal Cancer Patient Through Treatment

Back when D.N. Chadha, MA, was a pharmaceutical executive meeting with Jeffrey Meyerhardt, MD, MPH, in 2002, he never imagined he’d see the physician years later – this time for rectal cancer treatment. “The name rang a bell, and as soon as I saw him, I knew,” says Chadha, 74, […]

May 16, 2016
0
Cancer research
What Is a Liquid Biopsy?

A traditional biopsy is a test in which a piece of tissue is removed from a patient for analysis in a laboratory. A pathologist examines the tissue under a microscope, noting the shape, structure, and internal activity of the cells to determine whether the cells are cancerous and, if so, […]

April 20, 2016
0
Cancer research
How Scientists Aim to Expand Immunotherapy Options for Cancer Patients

This post also appeared on the NERD (Novartis Explores Research & Development) blog. By Eric Bender Fighting cancer with immunotherapy has revolutionized treatment for some patients. Emphasize “some.” For most patients, drugs targeting the immune system to attack their tumors aren’t an option. This could change in the near future. […]

April 14, 2016
0
Cancer research , Care for adults
FDA Approval of Defibrotide Brightens Outlook for Stem Cell Transplant Patients

Patients and Dana-Farber researchers alike welcomed this week’s Food and Drug Administration (FDA) approval of a new drug for a potentially fatal side effect of stem cell transplants. The approval means patients can receive the drug, defibrotide, as standard therapy for hepatic veno-occlusive disease (VOD) of the liver, a dangerous […]

March 31, 2016
0
Cancer research
Can We Treat Colorectal Cancer With Immunotherapy?

This post originally appeared on Cancer Research Catalyst, the official blog of the American Association for Cancer Research (AACR). It is posted here with minor edits. March is Colorectal Cancer Awareness Month. About 134,490 people are estimated to be diagnosed with and about 49,190 are expected to die from colorectal […]

March 21, 2016
0
Cancer research , Care for adults
How Precision Cancer Care Saved a Life

Ronaldo de Oliveira was close to death. The 33-year-old father of two young children had been diagnosed with myeloid sarcoma, a rare form of leukemia that worsened despite treatment with six different chemotherapy regimens. His wife pleaded with his oncologist, Richard Stone, MD, director of the Adult Leukemia Program at […]

March 18, 2016
0
Cancer research , Health and wellness
How Does Alcohol Cause Cancer?

This blog post was originally published on the Cancer Research UK science blog. It is reposted here with minor edits.   In a cabinet in London’s British Museum nestles a 5,300 year-old wedged-shaped tablet called a cuneiform. On its surface is scrawled one of the earliest forms of written language […]

March 3, 2016
0
Cancer research
What Makes Cancer Cells Different from Normal Cells?

Although they may seem like foreign invaders, cancer cells develop out of normal body cells and tissues. Over a period of years, damage to the DNA of healthy cells disrupts their orderly growth, leading to the formation of malignant tumors. Cancer cells may contain thousands of mutations – alterations in […]

March 2, 2016
0
Cancer research
The Cell that Caused Melanoma: Cancer’s Surprise Origins, Caught in Action

This post originally appeared on Vector, Boston Children’s Hospital’s science and clinical innovation blog. It’s long been a mystery why some of our cells can have mutations associated with cancer, yet are not truly cancerous. Now researchers have, for the first time, watched a cancer spread from a single cell […]

February 17, 2016
1
Cancer research
The Latest Research in Multiple Myeloma, Leukemia and Other Blood Cancers

The last two years have been very exciting for blood cancer research; many new targeted therapies and immunotherapies are improving treatment outcomes for patients with lymphoma, leukemia and multiple myeloma. “We’re starting to see a lot of hematologic malignancies benefit from immunotherapy,” says Irene Ghobrial, MD. “The excitement is there […]

February 11, 2016
0
Cancer research , Care for adults
What Are the Side Effects of Immunotherapy?

New drugs that stimulate the patient’s immune system to attack tumors have achieved some dramatic and long-lasting benefits in several forms of cancer. A few drugs are already approved for wide use and many more are in the research pipeline. Because these immunotherapy agents work differently than chemotherapy, they can […]

February 10, 2016
4
Cancer research , Care for children
In Precision Medicine, Pioneering Young Patient Teaches Veteran Doctor

Allison Schablein seems an unlikely candidate to teach medicine to Mark Kieran. She’s an 8–year-old New Hampshire second grader who loves basketball, hip hop, acrobatic dancing and jewelry. He’s a pediatric neuro-oncologist with a PhD in molecular biology, not to mention decades of clinical and research experience. But teach Kieran, […]

January 28, 2016
0
Cancer research
What A Cancer Cure ‘Moon Shot’ Might Look Like

This post originally appeared on WBUR’s CommonHealth blog. By Barrett Rollins, MD, PhD President Obama’s call for a new national effort against cancer – a “moon shot” – comes at a most opportune time. Cancer research has advanced significantly and now genomic analysis of individuals’ tumors can reveal the specific […]

January 14, 2016
2
Cancer research , Care for adults , Health and wellness
When Should I Begin Regular Mammograms? [Infographic]

For women weighing when to start having regular mammograms for early detection of breast cancer, the answer isn’t always clear. The American Cancer Society (ACS) recommendations, which were updated in October 2015, specify that women aged 45-54 who are at average risk should undergo yearly mammograms, and every two years […]

January 12, 2016
0
Cancer research , Care for adults
The Latest in Prostate Cancer Research and Treatment

Prostate cancer is the most common cancer affecting men in the United States, after skin cancer. Yet, “most men die with prostate cancer, not of prostate cancer,” says Mark Pomerantz, MD, a medical oncologist in Dana-Farber’s Lank Center for Genitourinary Oncology, who recently shared the latest in prostate cancer research […]

December 23, 2015
2
Cancer research
What Is CTLA-4 and How Does it Work in Treating Metastatic Melanoma?

Since the early 2000s, when Dana-Farber scientists discovered that many cancer cells carry “checkpoint” proteins that ward off an immune system attack on tumors, a great deal of research has focused on the development and testing of agents capable of blocking those proteins. In many patients, such agents have sent […]

December 15, 2015
0
Cancer research , Care for adults
Remission of Jimmy Carter’s Melanoma Shows Potential of Immunotherapy for Cancer

Former President Jimmy Carter’s announcement earlier this week that he is free of the melanoma that had spread to his liver and brain may be the highest-profile example yet of the promise of a new form of cancer treatment that unleashes an immune system attack on the disease. Carter, 91, […]

December 11, 2015
1
Cancer research
A New Class of Cancer Drug Moves Closer to Potential FDA Approval in Leukemia

Updated April 13, 2015 Venetoclax, a new type of cancer drug known as a Bcl-2 inhibitor, is showing great promise against a poor-prognosis form of chronic lymphocytic leukemia (CLL), and could work in other cancers as well. Venetoclax, formerly known as ABT-199, attacks the protein molecule, Bcl-2, that allows cancer […]

December 6, 2015
0
Cancer research
Immunotherapy and Lung Cancer: Exploring the Latest Research

The year 2015 marked a milestone in the treatment of lung cancer, with two new immunotherapy drugs approved for patients with advanced disease, bringing a new approach to this hard-to-treat cancer. Several other immunotherapy agents are also moving forward in clinical trials. In the past few years, scientists have found […]

November 18, 2015
1
Cancer research , Care for adults
FDA Approves New Drug for Some Patients with Non-Small Cell Lung Cancer

The FDA announced today it has approved a new pill to treat certain patients with advanced non-small cell lung cancer (NSCLC). The oral medication, Tagrisso (osimetinib), has been approved for NSCLC patients whose tumors have a specific epidermal growth factor receptor (EGFR) mutation (T790M) and whose disease has worsened after […]

November 13, 2015
0
Cancer research
Hot Topics in Immunotherapy and Targeted Therapy

This blog post is an excerpt from a Q&A posted on the Cancer Research Catalyst blog, the official blog of the American Association for Cancer Research. The interview was done with Dana-Farber’s Levi Garraway, MD, PhD, in advance of the International Conference on Molecular Targets and Cancer Therapeutics.   What […]

November 12, 2015
0
Cancer research , Care for adults
The Latest in Genetics and Women’s Cancers

Knowledge of genetics and women’s cancers has come a long way in the 20 years since the BRCA1/2 genes were discovered. Scientists are able to identify more genes that can increase risk, leading to better prevention and improved treatment. “One of the most exciting developments is the knowledge that patients […]

October 29, 2015
0
Cancer research , Health and wellness
The Link Between Processed Meat and Cancer: What You Need to Know [Infographic]

Eating processed meat products, such as hot dogs and bacon, can increase a person’s risk for colorectal cancer, according to research from an international cancer agency. The International Agency for Research on Cancer (IARC), the cancer agency of the World Health Organization (WHO), said today that processed meat is “carcinogenic […]

October 27, 2015
6
Cancer research
FDA Approves Immunotherapy Drug Combination for Melanoma

This blog post originally appeared on Cancer Research Catalyst, the official blog of the American Association for Cancer Research. By Karen Honey, PhD Last week, new ground was broken in the field of cancer immunotherapy when the U.S. Food and Drug Administration (FDA) approved the first cancer treatment to combine […]

October 6, 2015
0
Cancer research , Care for adults
What Is CA-125?

CA-125, the abbreviated name for cancer antigen 125, is a protein that’s often elevated in ovarian cancer as well as other types of cancers, such as those of the lung and breast. It’s also elevated when disease or inflammation arises in the pleura – the tissue that enfolds the lungs […]

September 28, 2015
0
Cancer research , Care for adults
Can Two Ovarian Cancer Drugs Succeed Where Others Have Failed?

When Donna Gregory’s ovarian cancer came back for the third time, she began looking for alternatives to chemotherapy. She’d been diagnosed with stage III ovarian cancer in 2003, at age 58. After having surgery to remove her tumors, she tried platinum-based chemotherapy, but her cancer did not respond. Several more […]

September 21, 2015
2
Cancer research , General interest
Federally Funded Research Can Power Progress Against Cancer

This post originally appeared on the AACR Cancer Research Catalyst Blog. This week, the American Association for Cancer Research (AACR) released the results of a national survey on American voters’ opinions about cancer and cancer research funding in conjunction with its fifth annual Cancer Progress Report. The report highlights how […]

September 18, 2015
0
Cancer research
What Is a Checkpoint Inhibitor? Immune Checkpoint Inhibitor Definition

Immune checkpoint inhibitors are drugs – often made of antibodies – that unleash an immune system attack on cancer cells. They’ve scored some impressive successes in recent years, particularly in some patients with metastatic melanoma or Hodgkin lymphoma, and are showing promise in clinical trials involving patients with other types […]

September 9, 2015
0
Cancer research
Finding the Best Targets for Precision Cancer Treatment

The inner world of a cancerous tumor is a place of intense rivalry, subversion, and aggression. Multiple subgroups of malignant cells – each with its own pattern of molecular features – vie with one another for nutrients, access to the blood supply, and room to grow and spread. This diversity, […]

September 4, 2015
0
Cancer research , Care for children
Childhood Cancer and the Promise of Gene Therapy

At its most basic level, gene therapy is a powerful technique for correcting mistakes (called mutations) in DNA of human cells. Lately, the therapy has been gaining traction as a potentially life-saving treatment for children with an array of inherited rare blood and immune disorders, as well as certain cancers. […]

August 21, 2015
0
Cancer research , Care for children
Progress in the Treatment of Childhood Leukemia

Although treatments for childhood cancer patients are improving, cancer remains the leading cause of death by disease in children. Doctors and researchers are also focused on decreasing the toxicity of these treatments, which can have side effects years after a child finishes treatment. “The war against childhood cancer is hardly […]

August 13, 2015
1
Cancer research , Care for adults
I Have Metastatic Breast Cancer: What’s My Prognosis?

By Rachel A. Freedman, MD, MPH Metastatic breast cancer generally means that the cancer has spread beyond the breast and nearby lymph nodes under the arm. For approximately 10 percent of women with breast cancer, the disease has metastasized when they are first diagnosed, but metastatic disease can also occur […]

August 12, 2015
1
Cancer research , Care for adults
Do All BRCA Mutations Come with the Same Cancer Risk?

Women born with mutations in the genes BRCA1 or BRCA2 have an increased risk of developing breast and ovarian cancer, but the degree of increase depends on a variety of factors. Not all mutations within these genes raise the risk equally. A study published earlier this year tracked breast and ovarian […]

July 29, 2015
2
Cancer research , Health and wellness
Why I Ride: Dr. Christopher Sweeney

Since 1980, more than 88,000 cyclists have taken to Massachusetts’ roads for the Pan-Mass Challenge (PMC) to raise funds for cancer research and patient care at Dana-Farber. Among the riders are many patients, their family members, and their doctors. Christopher Sweeney, MBBS, medical oncologist in Dana-Farber’s Lank Center for Genitourinary […]

July 27, 2015
0
Cancer research
Solving Puzzles with Cigall Kadoch

Growing up in the San Francisco area, Cigall Kadoch, PhD, had a passion for puzzles. The daughter of a Moroccan-born, Israeli-raised father and a mother from Michigan who together developed an interior design business, Kadoch excelled in school and pretty much everything else. Above all, she loved to solve brain-teasers. […]

July 23, 2015
1
Cancer research , Care for adults
Approval of Targeted Lung Cancer Drug Iressa Culminates Long Research Trail

The Food and Drug Administration’s approval of the drug Iressa® for a form of metastatic lung cancer represents a return to prominence for the compound that launched the era of targeted therapy in lung cancer – even if that wasn’t clear at the time of its original clinical trial in patients. […]

July 16, 2015
1

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